Yun Freudenberg-Hua, MD

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Associate Professor, Psychiatry and Molecular Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
Associate Professor, Litwin Zucker Center for Alzheimer's Disease, Feinstein Institutes for Medical Research

About the investigator

Dr. Freudenberg-Hua is an associate professor of psychiatry, molecular medicine and genetics in the Feinstein Institutes’ Litwin-Zucker Alzheimer’s Research Center and the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell. She is also an attending psychiatrist at the Geriatric Center at the Zucker Hillside Hospital.

Dr. Freudenberg-Hua received her medical degree from the University of Hamburg in Germany. Following clinical and research work in Medical Genetics at the University of Bonn School of Medicine, she completed her medical specialization in General and Geriatric Psychiatry at Hofstra Northwell School of Medicine.

For interest in research participation please call (516) 562-3492 or email [email protected]. For patients with memory problems and their care givers who would like to schedule a clinic appointment, please call (718) 470-8140.

Research focus

Dr. Freudenberg-Hua investigates the genetic factors of neurodegenerative diseases such as Alzheimer’s Disease. She performs computational analyses comparing the genomes of patients who suffer from Alzheimer’s disease with the genomes of subjects who remain cognitively healthy even at exceptionally advanced age. Her work integrates information about genome function from large databases with genetic and medical data. When combined with clinical information, such genetic insights can not only improve disease risk prediction and diagnosis precision, but also lead to novel preventive and therapeutic measures against dementia.

Lab information

Robert Adelson, BE
Research Data Analyst

Education

Hamburg University Medical School
Degree: MD

Institute for Human genetics, University of Bonn
Degree: Residency
Field of study: Human genetics

Zucker Hillside Hospital, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
Degree: Residency
Field of study: Psychiatry

Zucker Hillside Hospital, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
Degree: Fellowship
Field of study: Geriatric psychiatry

Honors & awards

2019 Scientific Achievement Award presented by Advancing Women in Science and Medicine
2018 Scientific Achievement Award presented by Advancing Women in Science and Medicine
2017 National Institute on Aging /National Institute of Health K08 Award
2017 Davison and Polsky Research Award
2012 NIMH Summer Research Institute in Geriatric Mental Health
2010 Honors Scholar of Geriatric Mental Health Foundation (GMHF)

Publications

Fulton-Howard B, Goate AM, Adelson RP, Koppel J, Gordon ML; Alzheimer's Disease Genetics Consortium, Barzilai N, Atzmon G, Davies P, Freudenberg-Hua Y. Greater effect of polygenic risk score for Alzheimer's disease among younger cases who are apolipoprotein E-e4 carriers. Neurobiol Aging. 2020. PMID: 33164815
Hunter LE, Freudenberg-Hua Y, Davies P, Kim M, Lipton RB, Stewart WF, Srinivasan P, Hu S, Lipton ML. Associations of Apolipoprotein E e4 Genotype and Ball Heading With Verbal Memory in Amateur Soccer Players. JAMA Neurol. 2020. PMID: 31985774
Freudenberg-Hua Y, Li W, Davies P. The Role of Genetics in Advancing Precision Medicine for Alzheimer’s Disease-A Narrative Review. Front Med. 2018 Apr 24;5:108. doi: 10.3389/fmed.2018.00108.
Freudenberg-Hua Y, Li W, Abhyankar A, Vacic V, Cortes V, Ben-Avraham D, Koppel J, Greenwald B, Germer S; T2D-GENES Consortium, Darnell RB, Barzilai N, Freudenberg J, Atzmon G, Davies P. Differential burden of rare protein truncating variants in Alzheimer's disease patients compared to centenarians. Hum Mol Genet. 2016 Jul 15;25(14):3096-3105. doi: 10.1093/hmg/ddw150. PMID: 27260402; PMCID: PMC5181592.
Freudenberg-Hua Y, Freudenberg J, Vacic V, Abhyankar A, Emde AK, Ben-Avraham D, Barzilai N, Oschwald D, Christen E, Koppel J, Greenwald B, Darnell RB, Germer S, Atzmon G, Davies P. Disease variants in genomes of 44 centenarians. Mol Genet Genomic Med. 2014;2(5):438-50.

Freudenberg J, Gregersen PK, Freudenberg-Hua Y. A simple method for analyzing exome sequencing data shows distinct levels of nonsynonymous variation for human immune and nervous system genes. PLoS One. 2012;7(6):e38087.
Winantea J, Hoang MN, Ohlraun S, Rietschel M, Cichon S, Propping P, Nöthen MM, Freudenberg J, Freudenberg-Hua Y. A summary statistic approach to sequence variation in noncoding regions of six schizophrenia-associated gene loci. Eur J Hum Genet. 2006;14:1037-1043.
Freudenberg-Hua Y, Freudenberg J, Kluck N, Cichon S, Propping P, Nothen MM. Single nucleotide variation analysis in 65 candidate genes for CNS disorders in a representative sample of the European population. Genome Res. 2003; 13:2271-2276.

View more at PubMed

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