Dr. Miller is a third tier trained therapeutic endoscopist and is board certified in internal medicine, gastroenterology and clinical nutrition. In addition, he is a trained bench lab and clinical research scientist, having completed a three year research fellowship at the Digestive Disease Section of the NIDDK. He currently hold the position as Chief of Gastroenterology Zucker School of Medicine. Dr. Miller has spent the last 30 years of his clinical career as a therapeutic endoscopist, performing ERCP and EUS. He spent much of his research career as head of endoscopic research at both Thomas Jefferson University and at Temple University in Philadelphia.
Part of Dr. Miller’s research interests are the design and invention of endoscopic devices. He has invented and patented a number of different endoscopic devices. In the early 1990’s, he invented a method using simultaneous high-resolution ultrasound and manometry to study the anatomy and physiology of gastrointestinal sphincters. Over the last 25 years of his academic career he used this technology to studying the anatomy and physiology of gastrointestinal sphincters and has published extensively on the anal sphincter, the lower esophageal sphincter, the upper esophageal sphincter, and the pyloric sphincter. As part of his NIH sponsored research work he studies the mechanics, physiology and pathophysiology of the high pressure zone of the distal esophagus.
Dr. Miler’s first RO1 grant dealt specifically with normal sphincter function and physiology of the distal esophageal anti-reflux barrier. In that grant he defined the anatomic and physiologic components of the distal esophageal high-pressure zone. Dr. Miller’s second NIH RO1 grant investigated the pathophysiology of GERD. Performing bench lab studies on muscle preparations from stomachs and esophagi of organ transplant donors and clinical studies, his lab discovered a number of new pathophysiologic mechanisms in GERD. These include 1) A contractile defect within the clasp/sling fiber complex. 2) Excessive relaxation of the clasp and sling fiber complex to nicotinic stimulation. 3) An abnormality within the muscularis mucosa in patients with GERD during deglutition. 4) Abnormal compliance of the gastroesophageal junction using various methods. 5) An attenuated cholinergic pressure profile within the circular smooth muscle of the distal esophagus. Dr. Millers current U18 NIH grant uses new techniques to implant gastric pacemakers in the submucosal space of the gastrointestinal tract.
For over 30 years, Dr. Miller has taught, researched and worked in the area of gastrointestinal physiology with a focus on sphincter mechanisms in the GI tract. As a principal investigator or co-investigator on several NIH-funded grants regarding the physiology and pathophysiology of the anti-reflux barrier at the gastroesophageal junction, he fully understands the time and commitment required to execute a research study effectively and efficiently.
The Chicago Medical School
Field of study: Medicine
University of Illinois
Field of study: Biology & Chemistry