Lance Becker, MD, FAHA is an investigator at the Feinstein Institutes for Medical Research and serves as the chair and professor of emergency medicine at the Zucker School of Medicine, and chair of the emergency departments at North Shore University Hospital and Long Island Jewish Medical Center. He is an internationally-recognized leader in the field of resuscitation, cardiac arrest, and critical care. His most impactful publications focused on question like “where are the survivors (from cardiac arrest)”, creating the Utstein international nomenclature for resuscitation, the original description of the three-phase model of cardiac arrest, reporting disparities in rates of cardiac arrest for minority populations, reappraisal of mouth-to-mouth ventilation, the instillation of AED’s in public settings, ischemia/reperfusion physiology, mitochondrial and metabolic approaches to resuscitation, and the critical descriptions of real-time quality of CPR measures during human cardiac arrest.
At the national level, Dr. Becker has publically advocated for NIH funding for resuscitation research as a leader of the PULSE Initiative that created multiple RFAs totaling over 150M dollars toward research in the last decade. He co-founded and chaired the American Heart Association’s Resuscitation Science Symposium which is the leading international venue for presentation of cutting edge resuscitation science, has served as chair of the AHA’s Peer Review subcommittee, chair of the Basic Life Support Committee, chair of the Cardiopulmonary, Perioperative, and Resuscitation Council, and helped establish the International Liaison Committee on Resuscitation (ILCOR) now responsible for the worlds recommendations on resuscitation practices. Dr. Becker is an elected member of the Institute of Medicine and National Academy of Medicine (IOM/NAM) has been a leader within the IOM/NAM efforts to improve survival from cardiac arrest and helped write the recent report “Strategies to Improve Survival from Cardiac Arrest: A Time to Act” and is currently working to develop a national Collaborative to improve survival from cardiac arrest.
Dr. Becker’s research focuses on the acute resuscitation of dying and critically sick patients. The Feinstein Lab group has developed several advanced animal models of critical illness and cardiac arrest. These experimental models are used to develop new treatments, new advanced biosensors, and to increase our understanding of ischemia/reperfusion physiology.
The laboratory has experience and expertise with the measurements of mitochondrial dysfunction, reactive oxygen and nitrogen species responses to ischemia, apoptotic activation following ischemia, signaling pathways, acute changes in lipid biochemistry following ischemia, changes in oxygen metabolism after ischemia, new cellular cytoprotective strategies and hypothermia protection strategies such as intra-arrest cooling. A unique aspect of the lab is an emphasis on bioengineering; this engineering perspective has been used to better understand the mechanisms of blood flow during CPR, and in using tissue auto-florescence as a measure of redox conditions within the cell and within tissues.
A current focus of his lab at the Feinstein Institutes for Medical Research is on developing emergency cardiopulmonary bypass coupled with advanced drugs to save lives of patients who fail traditional advanced cardiovascular life support (ACLS) treatment. An advanced animal model of emergency cardiopulmonary bypass has been developed to resuscitate animals following very prolonged periods of cardiac arrest. Experiments with multiple drugs targeted at reperfusion injury have been incorporated to improve neurological function for surviving animals, and a combination of drugs is currently under investigation for possible clinical use in the future.
A recent direction of the lab is to better define changes in oxygen consumption during resuscitation. The laboratory is trying to discern whether or not alterations in carbon metabolism and consumption of oxygen may signal the need for a new paradigm of alternative treatments in critically ill patients.
University of Illinois College of Medicine
University of Illinois
Field of Study: Biochemistry of Graduate Studies
University of Michigan