John Lovecchio, MD, Chief of Gynecologic Oncology at Northwell Health and Professor of Obstetrics and Gynecology at the Zucker School of Medicine, is one of the nation’s top clinicians and researchers in the field of uterine and ovarian cancers.
Dr. Lovecchio holds administrative and leadership positions in numerous regional and national organizations and has published extensively. He earned his B.S. degree magna cum laude from the University of Massachusetts and has a Master’s degree in nuclear physics from New York University. After completing his medical degree with honors from the State University of New York at Buffalo, he then completed his residency in Obstetrics and Gynecology at the University Hospitals of Case Western Reserve University and fellowship in Gynecologic Oncology at the University of Miami School of Medicine.
Recently, Dr. Lovecchio was featured in a PBS television documentary titled, “The Whisper: The Silent Crisis of Ovarian Cancer.”
Dr. Lovecchio is the lead investigator in a collaboration between Northwell Health and the Feinstein Institutes for Medical Research to advance the development of a blood test for the early detection of ovarian cancer. The team has been studying the presence and levels of biomarkers such as microRNAs (miRNAs) in diseases. MiRNAs are small (19-25nt), noncoding RNAs that regulate gene expression post-transcriptionally by binding in the 3’ untranslated region (3’UTR) of their specific messenger RNAs and interfering with translation. They are involved in normal cellular development, differentiation and proliferation. However, dysregulation of miRNA expression can have a causal role in malignancies. The presence and expression levels of specific tissue miRNAs have been associated with different types of cancer and clinical outcome. MiRNAs are remarkably stable and are well preserved in formalin fixed, paraffin embedded tissue samples and have been detected in plasma and serum samples, making them ideal candidates for non-invasive biomarkers of disease.
University Of Massachusetts, Boston, Massachusetts
Degree: BS – magna cum laude
Field of study: Biology
Long Island University, Brookville, New York
Degree: MS – summa cum laude
Field of study: Radiation Biology
State University of New York at Buffalo – Buffalo, New York
Case Western Reserve University, Cleveland, OH
Field of study: Obstetrics and Gynecology
University of Miami, Miami, FL
Field of study: Gynecologic Oncology