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  • Associate Professor, Center for Bioelectronic Medicine, Feinstein Institutes for Medical Research
  • Director, Orthopaedic Research Laboratory, Feinstein Institutes for Medical Research
  • Associate Professor, Molecular Medicine and Orthopedic Surgery, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell

About the investigator

Dr. Grande is widely recognized as a world leader in cartilage repair. He pioneered the first cell-based therapy for articular cartilage repair. These studies led to the commercialization of cartilage transplantation for the current surgical treatment of focal cartilage defects in clinical use today—autologous chondrocytes transplantation.

Dr. Grande is the AVP for Research Services as well as the director of Orthopaedic Research at the Feinstein Institutes for Medical Research. He also is a full professor at the Feinstein Institutes and a professor at the Elmezzi Graduate School of Molecular Medicine and the Zucker School of Medicine.

Dr. Grande graduated from Long Island University with a BS in Biology and completed his PhD in Anatomy and Cell Biology at New York University. He completed his post-doctorate in Biomechanics at the Hospital for Special Surgery. He began his scientific career at Hospital for Joint Diseases/Orthopedic Institute studying regenerative medicine and tissue engineering technologies for repair of the musculoskeletal system. In 1990, Dr. Grande established the orthopedic research laboratory at the Feinstein Institutes for Medical Research and continues investigating novel regenerative therapies including stem cells, growth factors, biomaterials and 3D bioprinting.

He is the author of over 100 peer review publications and seven book chapters. He has been awarded nine patents and helped found two companies in the orthopedic surgery field of use. Dr. Grande serves on many committees within the United States and internationally. He regularly serves on committees doing grant reviews and regularly serves on NIH study sections for R01, R21 and SBIR/STTR grants. He is on the editorial board of the journals Cartilage and Osteoarthritis and Cartilage.

Research focus

The original focus of Dr. Grande's work is articular cartilage repair and biology. He developed the first cell based therapy for restoration of cartilage defects called autologous chondrocyte implantation. This was the first FDA approved cell based therapy available to orthopedic surgeons. However, over the years, he has leveraged his skill set including tissue engineering, stem cells, biomaterials and biomechanics to other applications within the musculoskeletal system including meniscus, intervertebral disc, tendon and bone. This was partially motivated by residents interested in projects that supported their fellowship applications and partially by Dr. Grande's own intellectual curiosity.

He has published over 100 peer reviewed articles in both high impact journals such as Nature Reviews Rheumatology and Advanced Functional Materials as well as the top orthopedic journals including Clinical Orthopedics, Journal of Bone and Joint Surgery, American Journal of Sports Medicine and the Journal of Orthopedic Research. In addition, he has published several book chapters and editorials.

Recent work published by Dr. Grande's lab has focused on the new field of 3D bioprinting. They have initiated a number of applications that this technology is ideally suited. He also has extensive research collaborations and appointments with other departments including Uro-GYN and ENT involving biomaterials and tracheal reconstruction. 

Lab members

Hudson Liang, MD
Lab Manager and Assistant Investigator

Dan Li, PhD
Research Scientist

Andrew Wong, BSE
Research Associate

Pooja Swami, MS
Research Associate

Lidia Frejo Navarro, PhD
Post-Doc Researcher

Timothy Reed, MS2
Visiting Scholar

Ann Tran, MD
Urogynecology Fellow
OB/GYN Dept. 

Henintsoa Fanjaniaina A., BE
Visiting Scholar

Jedediah Bondy, BS
Visiting Scholar

Education

Long Island University
Degree: BS
1978
Field of study: Biology/chemistry

New York University
Degree: PhD
1986
Field of study: Anatomy/cell biology

Hospital for Special Surgery
Degree: Post-doc
1986
Field of study: Biomechanics

Appointments

  • 2018 – Present Full Professor of Orthopedic Surgery, Molecular Medicine, Urogynecology and Otolaryngology; Feinstein Institutes for Medical Research
  • 2018 – Present Full Professor of Orthopedic Surgery, Molecular Medicine, Urogynecology and Otolaryngology; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
  • 2018 – Present Assistant Vice President for Research Services, Feinstein Institutes, overseeing Scientific Cores, the Center for Comparative Physiology (CCP), the Institutional Animal Care and Use Committee (IACUC) and Biosafety
  • 2018 – Present Chair, Elmezzi Graduate School of Molecular Medicine Admissions Committee
  • 2017 – Present Member, Elmezzi Graduate School of Molecular Medicine Steering Committee
  • 1998 – Present Director, Resident Research; Dept. of Orthopaedic Surgery, Long Island Jewish Medical Center, New Hyde Park, NY
  • 1990 – Present Director, Orthopaedic Research Laboratory, North Shore University Hospital, Manhasset, NY
  • 2015 – 2018 Chair, Feinstein Institutes, IACUC
  • 2013 – 2015 Vice Chair, Feinstein Institutes, IACUC
  • 2013 – Present NS/LIJ Annual Academic Day Podium Presentation Competition Chair
  • 2011 – Present NS/LIJ Annual Academic Day Planning Committee: Organization and judging of annual systemwide academic competition
  • 2010 – Present Research Committee Co-Chair, Dept .of Orthopaedic Surgery: Mentoring and directing of orthopedic surgery resident research activities
  • 2010 – 2012 Hofstra School of Medicine, Admissions committee member
  • 2009 – Present Inaugural faculty, Zucker School of Medicine; helped in constructing curriculum for musculoskeletal portion of basic science course work
  • 2009 – 2011 Director of Operations, Feinstein Institutes for Medical Research
  • 2008 – Present Appointment in Dept. of OB/GYN; medical appointment to help facilitate basic research in surgical OB/GYN soft tissue reconstruction
  • 2006 – 2011 GCRC Advisory Committee, Feinstein Institutes for Medical Research
  • 2004 – 2010 Associate Professor, orthopedic surgery, Albert Einstein College of Medicine
  • 2003 – Present NIH Study section ad hoc member, special emphasis panel in orthopedics [MOSS]
  • 2003 – 2010 NS/LIJ Institute for Medical Research, in house Grant Review Committee
  • 2003 – Present NS/LIJ Institute for Medical Research, Intellectual Property Committee
  • 2000 – 2016 Associate Investigator, Scientific Track, Feinstein Institutes
  • 1998 – Present NS/LIJ Dept. of Orthopaedic Surgery Residency Selection Committee
  • 1998 – Present NS/LIJ Dept. of Orthopaedic Surgery Residency Review Committee

Honors & awards

  • 1989 Fabian Scientific Award: Hospital for Joint Diseases 
  • 1990 Arthroscopy Assoc. of North Am. Resident Research Award
  • 2001 American Orthopaedic Assoc. Resident Research Award (NE Region)
  • 2001 American Orthopaedic Assoc. Zimmer Award. Resident Research Award
  • 2001 Orthopaedic Research and Education Foundation NE Region Resident Competition
  • 2003 Outstanding Achievement in Orthopaedics Award
  • 2004 Charles S. Neer, MD Award. American Shoulder and Elbow Surgeons
  • 2005 Orthopaedic Research Society: New Investigator Research Award
  • 2004 New York Hand Society, Second place in the resident research competition 
  • 2007 Arthur Weber, MD Memorial Resident Appreciation Award 
  • 2007 North Shore/ LIJ Health System Outstanding Teacher Award
  • 2009 New York Society for Surgery of the Hand; second prize 
  • 2011 Best abstract at the Global Spine Congress
  • 2015 Presidents Award for Innovation. Finalist in the system wide competition for Northwell Health.
  • 2016 Presidents Award for Innovation- Winner in the system-wide competition for Northwell Health. 
  • 2016 Best overall paper at the 2016 Orthopaedic Fellow & Resident Summit. 
  • 2017 Innovate Long Island. Innovator of the Year Award
  • 2017 The Feinstein Institutes of Medical Research, Excellence in Research Award 2017. 
  • 2017 ICRS Order of Merit Award, presented at ICRS Heritage Summit Meeting, Gothenburg, Sweden
  • 2017 EOA/OREF Resident/Fellow Travel Grant
  • 2018 The Society of Thoracic Surgeons 54th Annual Meeting. Best Scientific Poster General Thoracic Surgery

Publications

  1. Grande DA. “Biomechanical and Geometric Characterization of Peroneus Longus Allografts with Respect to Age”. J Clinical Biomechanics. 2019
  2. Kaye R, Goldstein T, Grande DA, Zeltsman D, Smith LP. “A 3-Dimensional Biopritned Tracheal Segment Implant Pilot Study: Rabbit Tracheal Resection with Graft Implantation” In J Pediatric Otorhinolaryngol. 2018 Nov 10: 117: 175-178. PMID: 30579077
  3. Norelli JB, Plaza DP, Stal DN, Varghese AM, Liang H, Grande DA. “Tenogenically Differentiated Adipose-Derived Stem Cells are Effective in Achilles Tendon Repair In Vivo.” J of Tissue Engineering, Volume 9: 1-20, 2018
  4. Kaye R, Goldstein T, Grande DA, Zeltsman D, Smith LP. “A 3-Dimensional Bioprinted Tracheal Segment Implant Pilot Study: Rabbit Tracheal Resection with Graft Implantation.” Intl Journal of Pediatric Otorhinolaryngology, 117 (2019) 175-178
  5. Kisday JD, Schwartz JA, Tangtrongsup S, Goodrich LR, Grande DA. “Culture Conditions that Support Expansion and Chondrogenesis of Middle-Aged Rat Mesenchymal Stem Cells”. Article, July 2018 – Cartilage
  1. Coury JR, Nixon R, Collins M, Schwartz J, Chahine NO, Grande DA. “Oral Administration of a Chemically Modified Curcumin, TRB-N0224, Reduced Inflammatory Cytokines and Cartilage Erosion in a Rabbit ACL Transection Injury Model.” Cartilage, Nov. 2018 (Manuscript ID CART-18-027.R1
  2. Grande DA. “The Efficacy and Safety of a Percutaneous Tenotomy System for the Debridement of Tendinopathic Tissues” Journal of Long-Term Effects of Medical Implants. 28(3): 199-203; 2018
  3. O’Shaughnessy DI, Winkler H, Norelli JB, Varghese AM, Shalom D, Pillalamarri N, Lind L, Grande DA. “Biomechanical Properties of Poly-4-Hydroxybutyrate Mesh Compared to Polypropylene Mesh in a Rabbit Model: 3-Month Time Point”. American Journal of Obstetrics and Gynecology. 2018 Feb; 218(2):S898-S899
  4. Poon S, Chen YH, Wendolowski S, Graver A, Nixon R, Amaral T, DiMauro JP, Walz M, Gecelter R, Grande DA. A Cadaveric Study on Safety and Device Functionality of Magnetic-Controlled Growing Rods after Exposure to Magnetic Resonance Imaging.” Spine Deformity. Nov. 14, 2017
  5. Asnis S, Mullen J, Asnis PD, Sgaglione N, LaPorta T, Grande DA, Chahine NO. “Biomechanical Analysis of an Interference Screw and Novel Twist Lock Screw Design for Bone Graft Fixation”. Clinical Biomechanics 50(2017) 99-104
  6. Poon S, Chen YH, Graver A, Nixon R, Grande DA. “A Cadaveric Study on Safety and Device Functionality of Magnetic-Controlled Growing Rods (MCGRs) after Exposure to Magnetic Resonance Imaging (MRI).” The Spine Journal, October 2017
  7. Nguyen QT, Norelli JB, Graver A, Ekstein C, Schwartz J, Chowdhury F, Drakos MC, Grande DA, Chahine NO. “Therapeutic Effects of Doxycycline on the Quality of Repaired and Unrepaired Achilles Tendons”. Amer Journal of Sports Medicine. Volume XX, No. X. 2017
  8. Drakos MC, Gott M, Karnovsky SC, Murphy CI, DeSandis BA, Chinitz N, Grande DA, Chahine N. “Biomechanical Analysis of Suture Anchor vs. Tenodesis Screw for FHL Transfer.” Foot Ankle Int. 2017 Apr 1: Doi: 1177/1071100717702848. [Epub ahead of print] PubMed PMID: 28460573.
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