Dr. Grande is widely recognized as a world leader in cartilage repair. He pioneered the first cell-based therapy for articular cartilage repair. These studies led to the commercialization of cartilage transplantation for the current surgical treatment of focal cartilage defects in clinical use today—autologous chondrocytes transplantation.
Dr. Grande is the AVP for Research Services as well as the director of Orthopaedic Research at the Feinstein Institutes for Medical Research. He also is a full professor at the Feinstein Institutes and a professor at the Elmezzi Graduate School of Molecular Medicine and the Zucker School of Medicine.
Dr. Grande graduated from Long Island University with a BS in Biology and completed his PhD in Anatomy and Cell Biology at New York University. He completed his post-doctorate in Biomechanics at the Hospital for Special Surgery. He began his scientific career at Hospital for Joint Diseases/Orthopedic Institute studying regenerative medicine and tissue engineering technologies for repair of the musculoskeletal system. In 1990, Dr. Grande established the orthopedic research laboratory at the Feinstein Institutes for Medical Research and continues investigating novel regenerative therapies including stem cells, growth factors, biomaterials and 3D bioprinting.
He is the author of over 100 peer review publications and seven book chapters. He has been awarded nine patents and helped found two companies in the orthopedic surgery field of use. Dr. Grande serves on many committees within the United States and internationally. He regularly serves on committees doing grant reviews and regularly serves on NIH study sections for R01, R21 and SBIR/STTR grants. He is on the editorial board of the journals Cartilage and Osteoarthritis and Cartilage.
The original focus of Dr. Grande's work is articular cartilage repair and biology. He developed the first cell based therapy for restoration of cartilage defects called autologous chondrocyte implantation. This was the first FDA approved cell based therapy available to orthopedic surgeons. However, over the years, he has leveraged his skill set including tissue engineering, stem cells, biomaterials and biomechanics to other applications within the musculoskeletal system including meniscus, intervertebral disc, tendon and bone. This was partially motivated by residents interested in projects that supported their fellowship applications and partially by Dr. Grande's own intellectual curiosity.
He has published over 100 peer reviewed articles in both high impact journals such as Nature Reviews Rheumatology and Advanced Functional Materials as well as the top orthopedic journals including Clinical Orthopedics, Journal of Bone and Joint Surgery, American Journal of Sports Medicine and the Journal of Orthopedic Research. In addition, he has published several book chapters and editorials.
Recent work published by Dr. Grande's lab has focused on the new field of 3D bioprinting. They have initiated a number of applications that this technology is ideally suited. He also has extensive research collaborations and appointments with other departments including Uro-GYN and ENT involving biomaterials and tracheal reconstruction.
Hudson Liang, MD
Lab Manager and Assistant Investigator
Dan Li, PhD
Andrew Wong, BSE
Pooja Swami, MS
Lidia Frejo Navarro, PhD
Timothy Reed, MS2
Ann Tran, MD
Henintsoa Fanjaniaina A., BE
Jedediah Bondy, BS
Long Island University
Field of study: Biology/chemistry
New York University
Field of study: Anatomy/cell biology
Hospital for Special Surgery
Field of study: Biomechanics