Dr. Sharma has a broad background in multiple biological disciplines including microbiology, molecular biology, and immunology, with specific training in immune cell development and function in normal and infectious/inflammatory disease conditions. During her PhD, she identified small peptides using phage-displayed peptide libraries which can potentially be used for therapy and diagnosis of tuberculosis (TB) which resulted in a US patent. In her postdoctoral research training at the National Institute on Aging, NIH, she studied the role of betacatenin and T cell factor (TCF)-1, the two players in canonical Wnt-signaling pathway, in regulating the T cell and invariant Natural Killer T (iNKT) cell development and function. In 2013, Dr. Sharma joined the Feinstein Institutes for Medical Research as a research scientist, where she has studied the role of various immune cells and their signaling pathways, in particular involvement of extracellular cold-inducible RNAbinding protein (eCIRP), in animal models of sepsis and ischemia-reperfusion. In 2017, she was promoted to assistant professor at the Center for Immunology and Inflammation. More recently, she has studied the molecular mechanisms of how eCIRP causes inflammation and injury. Dr. Sharma has published over 25 articles in various peer-reviewed journals relating to various aspects of immune cell development and function, including high impact journals such as Nature Immunology and Oncogene. She is passionate about teaching and training, and has mentored/co-mentered summer students, post-baccalaureate fellows and surgery residents
Dr. Sharma's research focuses on studying the role of various immune cells and their signaling pathways, in particular involvement of extracellular cold-inducible RNA-binding protein (eCIRP), in animal models of sepsis and ischemia-reperfusion. More recently, she has studied the molecular mechanisms of how eCIRP causes inflammation and injury. Currently, she is studying eCIRP's role in Alzheimer’s disease-associated neuroinflammation and neurodegeneration.
National Institute on Aging, NIH, MD
Field of study: T Cell Immunology
Bose Institute, India
Field of study: Microbiology & Immunology