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The Feinstein Institutes supports a variety of state-of-the-art scientific core facilities that provide services to investigators. The scientific core facilities assist investigators and promote the highest quality research. The facilities are staffed with full-time professionals who can assist with the training in the use of instruments, conducting of assays and analysis of data. More information about our scientific cores is below. For questions regarding scheduling a core service, calendar access or billing, please contact Daniel Grande, PhD.

Flow Cytometry Core

The Flow Cytometry Core provides instrument support and daily assistance to users in a variety of flow cytometry-based techniques for both research and clinical applications. These include analysis of cell surface markers, analysis of expression of intracellular proteins and separation of cell suspensions into subgroups or single cells.

The facility views training as key to a well-functioning core with users that have a good grasp of both instrument theory and operation. This goes a long way toward empowering the investigator in the use of flow cytometry as a tool that leads to better, high quality level data with which to appropriate conclusions. The director of the core facility is available for training and to provide guidance and assistance. Please contact Chris Colon, core director, for further assistance and information.

For more information about the Flow Cytometry Core, please refer to the Northwell Health intranet. 

Microscopy Facility

The Light Microscopy Core Facility provides state-of-the-art optical imaging technologies that provide researchers insight into cellular features. The facility offers investigators support with design and troubleshooting of protocols, technical assistance with sample preparation, immunolabeling procedures and image analysis. Please contact Amanda Chan, PhD, manager, at [email protected] for more information.

For more information about the Microscopy Facility, please refer to the Northwell Health intranet

Molecular Biology Core Facility

The Molecular Biology Core Facility is at the heart of the Feinstein Institutes' rich collaborative program in genetics. We house a state-of-the-art genetics suite where scientists can have access to high-throughput genetic mapping technology that includes SNP and microsatellite analysis. Investigators can also carry out gene expression arrays and analysis of methylation differences across the human genome.

The facility offers help to researchers from a variety of other scientific fields who want to add a genetic component to their research, or who wish to examine the patterns of gene expression and regulation in various cells and tissues. The facility makes extensive use of robotic systems that facilitate rapid production of data and allow scientists more time to focus on data analysis. The core also offers consultation on assay development, validation, and configuration of assays for high throughput screening. For more information, contact Annette Lee, PhD. 

For more information about the Molecular Biology Core Facility, please refer to the Northwell Health intranet

Nursing Core

The Feinstein Institutes Nursing Core provides research clinical nursing solutions aimed at successfully implementing clinical studies and supporting research participants. We offer direct patient care throughout various stages of treatment on protocol and follow-up. We also facilitate the informed consent process and evaluation of patient eligibility for participation in a research study with the principal investigator, use expert nursing judgment to maintain the integrity of the research protocol in accordance with federal regulation and good clinical practice guidelines, ensure compliant conduct of the trial while maintaining patient safety, and provide emotional and educational support to research subjects, serving as liaison between them and the investigators.

We are also equipped with exam rooms, an infusion room, a medication room, rooms with specimen-processing ability and long term storage use, and a -80 degree freezer monitored by the Amega Monitoring System. For more information, contact Christine Demers at [email protected] or (516) 562-1012.

For more information about Nursing Core, please refer to the Northwell Health intranet

Quantitative PCR Core Facility

The Feinstein Institutes houses Quantitative PCR (QPCR) machines. QPCR, or real-time RT-PCR, is a sensitive, reproducible and accurate method for determining the DNA or mRNA levels in tissues or cells. The facility provides real-time PCR chemistries, consultation, experimental design consultation, assistance in data analysis and troubleshooting. Machines are available 24 hours per day. For more information, or if you have questions regarding the operation of the facility or other technical questions, please contact Valerie Boone at [email protected] or (516) 562-1096.

For more information about the QPCR Facility, please refer to the Northwell Health intranet

Micro Positron Emission Tomography (MicroPET) core

The main focus of the micro Positron Emission Tomography (MicroPET) core is the Siemens Inveon scanner capable of obtaining in-vivo metabolic and other biological information. Some of the common tracers used in the lab are 18F-flurodeoxyglucose (18FDG) to visualize cellular metabolism, 18F-fluorodeoxysorbitol (18FDS) to detect areas of infection, and oxygen-15 water ([15O]H2O) to image blood flow/perfusion. Special tracers can also be produced by the radiochemistry department and used in the MicroPET to measure inflammation such as 11C peripheral benzodiazepine receptor ligand (11C-PBR) and 11C-alpha-aminoisobutyric acid (11C-AIB) to quantify changes in blood-brain-barrier permeability. If you have any questions, contact Joseph Carrion at [email protected].

For more information about the micro Positron Emission Tomography core, please refer to the Northwell Health intranet.